Research has now revealed the mechanism underlying the anesthetic ketamine's rapid and sustained antidepressant effect: it activates an important signaling pathway in the prefrontal cortex of the brain. The findings provide clues that could lead to faster-acting drugs for depression or potentially even the adoption of current drugs for this use or augmentation of the effects of existing antidepressants.
Article at: http://sis.windhover.com/buy/abstract.php?id=2010900191&utm_source=toc&utm_medium=website